Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro.

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Population

Adult male Sprague-Dawley rats and cultured cardiac fibroblasts

Design

Preclinical

Follow-up

up to 14 days

Authors

Discussion

May suggest antifibrotic effects of thyroid hormone in experimental models; leaves open translation to human cardiac disease.

Population

Adult male Sprague-Dawley rats and cultured cardiac fibroblasts

Intervention

L-thyroxin (10 micrograms/100 g body wt intraperitoneally for up to 14 days in rats; 10 nM in cultured fibroblasts)

Outcome

Abundance of mRNA for pro alpha 2(I) collagen and collagen synthesissurrogate

Thyroid hormone induces myocardial hypertrophy while simultaneously decreasing collagen gene expression and synthesis, preventing fibrosis.

Yao et al. (1992) studied this question.

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