Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased β-myosin heavy chain gene expression

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Population

Cardiomyocytes prepared from hearts of neonatal Wistar rats

Comparison

3,3',5-triiodo-thyronine (T3) treatment vs Angiotensin II (Ang II) alone

Design

Preclinical

Authors

Discussion

T3 effects in this Ang II model are hypothesis-generating; clinical translation in human hypertrophy remains untested.

Population

Cardiomyocytes prepared from hearts of neonatal Wistar rats

Intervention

3,3',5-triiodo-thyronine (T3) treatment

Comparator

Angiotensin II (Ang II) alone

Outcome

Incorporations of [3H]-thymine and [3H]-leucine, MHC isoform mRNA expression, PKC activity, and PKC isoform protein expressionsurrogate

T3 can reprogram gene expression in Ang II-induced cardiac hypertrophy in vitro, potentially via a PKC signaling pathway.

Wang et al. (2006) studied this question.

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