January 1, 1991AJP Heart and Circulatory Physiology

Adaptational changes of MHC gene expression and isozyme transition in cardiac overloading

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Population

Coarctated (Coa) rats, sham-operated (Sham) rats, and normal rats

Comparison

Thyroid hormone administration and/or pressure… vs Sham-operated rats and normal rats without…

Design

Preclinical

Follow-up

77 days after surgery

Authors

SIShinichiro ImamuraHimeji Dokkyo University RMRumiko MatsuokaPediatric / Congenital Cardiology EHEriko HiratsukaJapan Research Institute

Discussion

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Implication

Thyroid-independent beta-MHC shifts in rodent overload warrant clinical caution; leaves open human mechanistic validation.

Structured PICO

Population

Coarctated (Coa) rats, sham-operated (Sham) rats, and normal rats

Intervention

Thyroid hormone (Thy) administration and/or pressure overload via coarctation

Comparator

Sham-operated rats and normal rats without thyroid hormone administration

Outcome

beta-MHC mRNA and isozyme levels, and serum thyroid hormone levelssurrogate

MHC isoform transitions induced by pressure overload are independent of serum thyroid hormone decreases, representing the first adaptational process to hemodynamic overload before hypertrophy.

Cite This Study

Imamura et al. (1991) studied this question.

synapsesocial.com/papers/6a73d0732212a44d888de734 https://doi.org/10.1152/ajpheart.1991.260.1.h73

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Adaptational changes of MHC gene expression and isozyme transition in cardiac overloading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adaptational changes of MHC gene expression and isozyme transition in cardiac overloading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider