Key result
Different models of muscular activity, inactivity, and thyroid hormone levels regulate myosin heavy chain gene expression in mammalian cardiac and skeletal muscle via transcriptional mechanisms.
This review highlights the marked plasticity of myosin heavy chain gene expression in mammalian striated muscle in response to mechanical loading and thyroid hormone status.
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Should not change cardiac practice; extends transcriptional mechanisms of MHC plasticity in striated muscle.
Baldwin et al. (2001) conducted a review in Myosin heavy chain gene expression in striated muscle. Muscular activity and inactivity paradigms was evaluated. Different models of muscular activity, inactivity, and thyroid hormone levels regulate myosin heavy chain gene expression in mammalian cardiac and skeletal muscle via transcriptional mechanisms.
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