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May 1, 1984Journal of Biological ChemistryOpen Access

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

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Key result

Thyroid hormone regulates cardiac ventricular alpha- and beta-myosin heavy chain genes in an antithetic fashion, determining the myosin phenotype through changes in mRNA levels.

Population

Preclinical model (cardiac ventricular myocardium, atrial myocardium, and soleus muscle tissues)

Comparison

Different thyroid hormone levels and… vs Baseline or alternative thyroid hormone levels…

Design

Preclinical

Authors

ALAnne‐Marie LompréHeart Failure / CardiomyopathyBNB Nadal-GinardKing's College LondonVMVijak MahdaviBoston Children's Hospital

Discussion

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Implication

Animal data warrant no change in thyroid management; leaves open human translation of myosin regulation.

Structured PICO

P
Population
Preclinical model (cardiac ventricular myocardium, atrial myocardium, and soleus muscle tissues)
I
Intervention
Different thyroid hormone levels and developmental stages
C
Comparator
Baseline or alternative thyroid hormone levels and developmental stages
O
Outcome
Temporal expression of alpha- and beta-MHC genes (mRNA levels) and corresponding isozymessurrogate

This study demonstrates that the cardiac ventricular myosin phenotype is determined by the antithetic regulation of alpha- and beta-MHC gene expression by thyroid hormone and developmental stages.

Cite This Study

Lompré et al. (1984) studied this question. Thyroid hormone regulates cardiac ventricular alpha- and beta-myosin heavy chain genes in an antithetic fashion, determining the myosin phenotype through changes in mRNA levels.

synapsesocial.com/papers/6a08db2b02034f20cae4aba3https://doi.org/10.1016/s0021-9258(20)82162-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural differences in the heavy chains of rat ventricular myosin isoenzymes1979 · 225 citations
  2. 2Isolation and characterization of two molecular variants of myosin heavy chain from rabbit ventricle. Change in their content during normal growth and after treatment with thyroid hormone.1982 · 143 citations
  3. 3Isomyosin distribution in normal and pressure-overloaded rat ventricular myocardium. An immunohistochemical study.1981 · 113 citations
  4. 4Cloned mRNA sequences for two types of embryonic myosin heavy chains from chick skeletal muscle. II. Expression during development using S1 nuclease mapping.1983 · 63 citations
  5. 5An Electrophoretic Study of Native Myosin Isozymes and of Their Subunit Content1979 · 283 citations