Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 2, 1984European Heart JournalOpen Access

Cardiac myosin heavy chain isozymic transitions during development and under pathological conditions are regulated at the level of mRNA availability

View Full Paper
Ask AI
Bookmark
Share

Key result

The level of fetal and adult ventricular MHC mRNAs accounts for the isozymic transitions of the myosin protein during normal development and pathological conditions.

Authors

VMVijak MahdaviBoston Children's HospitalALA LOMPREInsermACAilsa P. ChambersAustralian National University

Discussion

Loading...

Member takes

Implication

MHC mRNA levels underlie myosin transitions in development and disease; leaves open whether this informs therapies or outcomes in cardiomyopathy.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Mahdavi et al. (1984) studied this question. The level of fetal and adult ventricular MHC mRNAs accounts for the isozymic transitions of the myosin protein during normal development and pathological conditions.

synapsesocial.com/papers/6a96f01723945b24488246f7https://doi.org/10.1093/eurheartj/5.suppl_f.181
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of sarcomeric myosin heavy chain genes.1983 · 136 citations
  2. 2Structural differences in the heavy chains of rat ventricular myosin isoenzymes1979 · 225 citations
  3. 3The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.1981 · 201 citations
  4. 4Sarcomeric myosin heavy chain is coded by a highly conserved multigene family.1982 · 146 citations
  5. 5Cytoplasmic processing of myosin heavy chain messenger RNA: evidence provided by using a recombinant DNA plasmid.1980 · 76 citations