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This review examines how cardiac myosin heavy chain genes are regulated, particularly by T3.

May 1, 1993CirculationOpen Access

Regulation of myosin heavy chain genes in the heart.

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EMEugene MorkinUniversity of Arizona

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Implication

Species variability in T3 responsiveness of cardiac MHC genes cautions against rodent-to-human extrapolation; leaves open human-specific regulatory mechanisms for targeted study.

Key Points

This review examines how cardiac myosin heavy chain genes are regulated, particularly by T3.
Reviewed molecular cloning advancements for alpha- and beta-MHC genes.
Analyzed gene expression responsiveness to T3 across different mammals.
Identified regulatory elements via chimeric plasmids and transgenic models.
T3 stimulates alpha-MHC transcription while inhibiting beta-MHC mRNA production.
Gene responsiveness to T3 shows species variability: highest in rat and rabbit, lower in calf and baboon, very low in dog.
Regulatory elements affecting T3 response identified within the alpha- and beta-MHC promoters.

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Eugene Morkin (1993) studied this question.

synapsesocial.com/papers/6a23aee19e1c90a91c0916f7 https://doi.org/10.1161/01.cir.87.5.1451

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Implication

Species variability in T3 responsiveness of cardiac MHC genes cautions against rodent-to-human extrapolation; leaves open human-specific regulatory mechanisms for targeted study.

Regulation of myosin heavy chain genes in the heart.

Discussion

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Implication

Key Points

Cite This Study

Regulation of myosin heavy chain genes in the heart.

Discussion

Member takes

Implication

Key Points

Cite This Study

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