Key result
Combined hyperthyroidism and hindlimb suspension rapidly converted rat soleus into a fast muscle, producing large increases in fast type IIx and IIb MHC isoforms in unique hybrid fiber populations.
Population
Rat soleus muscle (n = 3,818 single fibers)
Design
Preclinical
Follow-up
1, 2, and 4 weeks
Authors
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Offers a potent rodent model for MHC plasticity studies; leaves open translation to human skeletal or cardiac muscle.
The combination of T3 and hindlimb suspension serves as a powerful model for manipulating and studying MHC isoform plasticity in slow skeletal muscle.
Caiozzo et al. (1998) studied Myosin heavy chain isoform composition in rat soleus muscle. Hyperthyroidism (T3) and hindlimb suspension (HS) vs. Separate effects of T3 and HS was evaluated on Myosin heavy chain (MHC) isoform composition. Combined hyperthyroidism and hindlimb suspension rapidly converted rat soleus into a fast muscle, producing large increases in fast type IIx and IIb MHC isoforms in unique hybrid fiber populations.
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