Key result
Unloading of rat soleus muscle by hindlimb suspension induced a slow-to-fast transition of myosin heavy chain isoforms in the order MHCIbeta to MHCIIa to MHCIId(x) to MHCIIb over 28 days.
Population
Rat soleus muscle unloaded by hindlimb suspension
Comparison
Hindlimb suspension (unloading) for up to 28 days vs Control soleus muscle
Design
Preclinical
Follow-up
Up to 28 days
Authors
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Should not yet inform human disuse management; hypothesis-generating for ordered MHC transitions in clinical muscle plasticity.
Unloading of rat soleus muscle induces a sequential slow-to-fast transition of myosin heavy chain isoforms, with MHCIalpha transiently upregulated as an intermediate step.
Sultan et al. (1999) studied Unloaded soleus muscle. Hindlimb suspension (unloading) vs. Control soleus was evaluated on Time-dependent changes in myosin heavy chain (MHC) isoform expression. Unloading of rat soleus muscle by hindlimb suspension induced a slow-to-fast transition of myosin heavy chain isoforms in the order MHCIbeta to MHCIIa to MHCIId(x) to MHCIIb over 28 days.
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