Population
Adult rats (single fibers from fast-twitch plantaris and slow-twitch soleus skeletal muscles)
Comparison
28 days of hindlimb suspension (hypokinesia) vs Control muscles
Design
Preclinical
Follow-up
28 days
Authors
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Should not guide human disuse protocols; leaves open myosin isoform shifts during clinical immobilization or microgravity.
Prolonged hypokinesia alters the myosin isozyme composition of skeletal muscle, which explains the observed changes in the maximal velocity of unloaded shortening in single muscle fibers.
Reiser et al. (1987) studied this question.
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