Population
Rat soleus muscle
Comparison
3 weeks hindlimb suspension vs Normal soleus muscle
Design
Preclinical
Follow-up
3 weeks
Authors
Loading...
Highlights unloading effects on myosin in rodents; extends mechanistic insight but leaves open human translation.
Hindlimb suspension in rats induces a shift towards fast myosin heavy chain isoforms in the soleus muscle, demonstrating adaptation of muscle contractile proteins to unloading.
Okumoto et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: