Population
Rat soleus muscle fibers
Comparison
Hindlimb suspension (HS) for 1, 2, and 3 weeks vs Control (no hindlimb suspension)
Design
Preclinical
Follow-up
Up to 3 weeks
Authors
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Animal data support unloading-induced fiber changes; leaves open human translation and clinical implications.
Hindlimb suspension in rats leads to progressive atrophy, decreased peak force, and altered contractile properties in soleus muscle fibers over 3 weeks.
McDonald et al. (1994) studied this question.
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