Why the study?
Does hindlimb unloading alter fiber type composition uniformly along the length of the soleus muscle in rats?
Population
13-15 week old female Wistar rats (n=23, weight 236-272g)
Comparison
Hindlimb unloading (HU) for 1 or 2 weeks vs Control group (normal weight-bearing)
Design
Preclinical, Randomized into 3 groups (1 wk HU, 2 wk HU, control)
Follow-up
1 or 2 weeks
Authors
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Non-uniform soleus fiber shifts after HU warrant regional sampling in rodent models; leaves open relevance to human disuse atrophy.
Does hindlimb unloading alter fiber type composition uniformly along the length of the soleus muscle in rats?
Hindlimb unloading induces non-uniform transformation of muscle fiber types along the length of the rat soleus muscle.
Okumoto et al. (1995) studied this question.
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