June 1, 1993Journal of Applied PhysiologyOpen Access

Effect of hindlimb unweighting on single soleus fiber maximal shortening velocity and ATPase activity

View Full Paper

Ask AI

Bookmark

Population

Single soleus muscle fibers from an animal model

Design

Preclinical

Follow-up

3 weeks

Authors

KMKerry S. McDonaldUniversity of Missouri RFR. H. FittsMarquette University

Discussion

Member takes

Implication

Rodent HU model shows faster soleus fibers; leaves open translation to human disuse atrophy and countermeasures.

Structured PICO

Population

Single soleus muscle fibers from an animal model

Intervention

Hindlimb unweighting (HU) for 1, 2, or 3 weeks

Outcome

Single soleus muscle fiber size, peak force, maximal velocity of shortening (Vo), myofibrillar ATPase activity, and relative content of slow and fast myosinsurrogate

Hindlimb unweighting progressively reduces soleus fiber size and force while increasing shortening velocity, ATPase activity, and fast myosin expression over 3 weeks.

Cite This Study

McDonald et al. (1993) studied this question.

synapsesocial.com/papers/6a729add2163a0a01bc6323a https://doi.org/10.1152/jappl.1993.74.6.2949

View Full Paper

Ask AI

Bookmark

Effect of hindlimb unweighting on single soleus fiber maximal shortening velocity and ATPase activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of hindlimb unweighting on single soleus fiber maximal shortening velocity and ATPase activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider