Key result
7-day hindlimb suspension induced reductions in cross-sectional area, peak force, and specific force of slow and fast soleus fibers across all three mouse strains.
Population
Three strains of mice (CBA/J, ICR, C57BL/6)
Comparison
7-day hindlimb suspension (HS) vs Weight-bearing
Design
Preclinical
Follow-up
7 days
Authors
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Findings from mouse disuse models warrant cautious translation; leaves open strain effects on human muscle atrophy.
In mouse models, 7-day hindlimb suspension induces fiber atrophy and contractile dysfunction that is partially dependent on animal strain but generally independent of fiber MHC isoform content.
Stelzer et al. (2003) studied this question. Hindlimb suspension vs. Weight-bearing was evaluated on Cross-sectional area (CSA), peak Ca2+-activated force (Po), fiber specific force (Po/CSA), and unloaded shortening velocity (Vo). 7-day hindlimb suspension induced reductions in cross-sectional area, peak force, and specific force of slow and fast soleus fibers across all three mouse strains.
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