Hypoxia enhances growth factor-induced DNA synthesis and increases basal collagen type I production in human cardiac fibroblasts, suggesting a mechanism for post-infarct remodeling of the collagen matrix in the failing heart.
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Hypothesis-generating for hypoxia-driven collagen remodeling in cardiac fibroblasts; leaves open mechanistic role in post-MI heart failure.
Agocha et al. (1997) studied this question.
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