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January 1, 1991Connective Tissue Research

Effect of Growth Factors on Collagen Metabolism in Cultured Human Heart Fibroblasts

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Population

Cultured human heart fibroblasts (HHF)

Design

Preclinical

Authors

CCChu Chang ChuaEast Tennessee State UniversityBCBalvin H.L. ChuaEast Tennessee State UniversityZZZ. Y. ZhaoNational Center for Chronic and Noncommunicable Disease Control and Prevention

Discussion

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Implication

bFGF/TGF-beta interactions may modulate cardiac fibroblast matrix turnover; leaves open in vivo effects on remodeling.

Structured PICO

P
Population
Cultured human heart fibroblasts (HHF)
I
Intervention
Basic fibroblast growth factor (bFGF) (10 ng/ml) alone and in combination with transforming growth factor-beta (TGF-beta)
O
Outcome
Gene expression of type I collagen, collagenase, and tissue inhibitor of metalloproteinases (TIMP)surrogate

TGF-beta and bFGF play a pivotal role in regulating collagen metabolism in human heart fibroblasts, providing mechanistic insights into cardiac extracellular matrix regulation.

Cite This Study

Chua et al. (1991) studied this question.

synapsesocial.com/papers/6a73e10176f4fb0e4269f3c4https://doi.org/10.3109/03008209109152444
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