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May 1, 2004American Journal of HypertensionOpen Access

Transforming growth factor-beta1-mediated collagen gel contraction by cardiac fibroblasts

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Population

Cardiac fibroblasts from male adult Wistar rats (passage 2)

Comparison

TGF-beta1 for 1, 2 and 3 days vs Without TGF-beta1 (0 pmol/l)

Design

Preclinical

Follow-up

1, 2, and 3 days

Authors

PLPaul Lijnen

Discussion

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Overview

Should not yet alter practice; hypothesis-generating for TGF-beta1 in cardiac fibroblast activation and fibrosis.

Structured PICO

P
Population
Cardiac fibroblasts from male adult Wistar rats (passage 2)
I
Intervention
TGF-beta1 (20, 40, 100, 200 or 600 pmol/l) for 1, 2 and 3 days
C
Comparator
Without TGF-beta1 (0 pmol/l)
O
Outcome
Area of the collagen gel (contractile activity)surrogate

TGF-beta1 increases the contractile activity of adult rat cardiac fibroblasts and promotes their differentiation into myofibroblasts.

Cite This Study

Paul Lijnen (2004) studied this question.

synapsesocial.com/papers/6a75ceb3b5de85d41819ca8dhttps://doi.org/10.1016/j.amjhyper.2004.03.454
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