What does this research mean for the field?

Transforming growth factor beta 1 (TGF-beta 1) specifically induces cardiac fibroblasts to differentiate into a myocyte-like phenotype expressing muscle-specific actin. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1991Proceedings of the National Academy of SciencesOpen Access

Cardiac fibroblasts are predisposed to convert into myocyte phenotype: specific effect of transforming growth factor beta.

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Why the study?

Does TGF-beta 1 induce myocyte-specific properties in cultured cardiac fibroblasts?

Population

Cultured cardiac fibroblasts from adult rabbit heart, NIH 3T3 cells, and human skin fibroblasts

Comparison

Transforming growth factor beta 1 10-15 ng/ml vs Untreated cells, or cells treated with phorbol…

Design

Preclinical

Follow-up

24 hours

Authors

MEM EghbaliAlbert Einstein College of Medicine RTR TomekUniversity of Chicago CWConnie W. WoodsUnion Institute & University

Discussion

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Implication

Hypothesis-generating for fibroblast plasticity; leaves open in vivo relevance to human cardiac remodeling.

Structured PICO

Does TGF-beta 1 induce myocyte-specific properties in cultured cardiac fibroblasts?

Population

Cultured cardiac fibroblasts from adult rabbit heart, NIH 3T3 cells, and human skin fibroblasts

Intervention

Transforming growth factor beta 1 (TGF-beta 1) 10-15 ng/ml

Comparator

Untreated cells, or cells treated with phorbol 12-myristate 13-acetate, norepinephrine, angiotensin II, or interleukin 1 beta

Outcome

Expression of sarcomeric actin mRNA and muscle-specific actinsurrogate

TGF-beta 1 specifically induces cultured adult rabbit cardiac fibroblasts to differentiate into cells displaying myocyte characteristics, such as expressing sarcomeric actin.

Cite This Study

Eghbali et al. (1991) studied this question.

synapsesocial.com/papers/6a1572b379ff98d0de4ea537 https://doi.org/10.1073/pnas.88.3.795

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Cardiac fibroblasts are predisposed to convert into myocyte phenotype: specific effect of transforming growth factor beta.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac fibroblasts are predisposed to convert into myocyte phenotype: specific effect of transforming growth factor beta.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider