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December 1, 1996AJP Heart and Circulatory Physiology

IK of rabbit ventricle is composed of two currents: evidence for IKs

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Population

Rabbit ventricular myocytes and Xenopus oocytes expressing the rabbit minK (IsK) gene

Design

Preclinical

Authors

JSJoseph J. SalataMerck & Co., Inc., Rahway, NJ, USA (United States)NJNancy K. JurkiewiczUnited States Military AcademyBJBrian JowUnited States Military Academy

Discussion

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Implication

Challenges assumption of IKr exclusivity in rabbit ventricle; leaves open relevance to human repolarization.

Structured PICO

P
Population
Rabbit ventricular myocytes and Xenopus oocytes expressing the rabbit minK (IsK) gene
I
Intervention
Pharmacological isolation and characterization of IKs using dofetilide, isoproterenol, and azimilide; Northern analysis for minK gene expression
O
Outcome
Presence and electrophysiological properties of the slow delayed rectifier K+ current (IKs)surrogate

Provides evidence that the slow delayed rectifier K+ current (IKs) is present in rabbit ventricle and contributes to cardiac repolarization, challenging the previous belief that only IKr was present.

Cite This Study

Salata et al. (1996) studied this question.

synapsesocial.com/papers/6a6fbcf9660549caf2c44827https://doi.org/10.1152/ajpheart.1996.271.6.h2477
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single delayed rectifier channels in the membrane of rabbit ventricular myocytes.1993 · 66 citations
  2. 2Two components of the delayed rectifier potassium current, IK, in rabbit sino‐atrial node cells1996 · 71 citations
  3. 3Molecular dissection of the inward rectifier potassium current (<i>I</i><sub>K1</sub>) in rabbit cardiomyocytes: evidence for heteromeric co‐assembly of K<sub>ir2.1</sub> and K<sub>ir2.2</sub>2003 · 125 citations
  4. 4Role of an inwardly rectifying potassium current in rabbit ventricular action potential.1992 · 167 citations
  5. 5Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.1990 · 1,472 citations