July 1, 1996Experimental PhysiologyOpen Access

Separation of the components of the delayed rectifier potassium current using selective blockers of IKr and IKs in guinea‐pig isolated ventricular myocytes

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Population

Guinea-pig isolated ventricular myocytes

Design

Preclinical

Authors

BHBryony HeathUniversity of Nottingham DTDerek A. TerrarUniversity of Oxford

Discussion

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Implication

Complementary blockers enable IKr/IKs separation in guinea-pig myocytes; leaves open translation to other models or species.

Structured PICO

Population

Guinea-pig isolated ventricular myocytes

Intervention

Selective blockers E4031 (5 microM) for IKr, and propofol (100 microM) or thiopentone (100 microM) for IKs, with nifedipine (2 microM) to block L-type calcium currents

Outcome

Separation of rapid (IKr) and slow (IKs) components of the delayed rectifier potassium current (IK)surrogate

E4031 and propofol or thiopentone are useful complementary tools for separating the rapid and slow components of the delayed rectifier potassium current in guinea-pig ventricular myocytes.

Cite This Study

Heath et al. (1996) studied this question.

synapsesocial.com/papers/6a6fbd22f44fa9f079dd3871 https://doi.org/10.1113/expphysiol.1996.sp003961

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Separation of the components of the delayed rectifier potassium current using selective blockers of IKr and IKs in guinea‐pig isolated ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Separation of the components of the delayed rectifier potassium current using selective blockers of IKr and IKs in guinea‐pig isolated ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider