Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry
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Why the study?
Does obesity reduce 2-year cardiac and all-cause death in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction?
Population
1,125 stabilized patients with type 2 diabetes mellitus after acute myocardial infarction, mean age 65, 66%…
Comparison
Obesity (defined as body mass index ≥25 kg/m2) vs Non-obesity (defined as body mass index <25 kg/m2)
Design
Cohort
Follow-up
2 years
Authors
Discussion
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Implication
Obesity paradox observed in stabilized Asian DM patients post-AMI; extends prior findings but leaves causal role of BMI open for prospective study.
Structured PICO
Does obesity reduce 2-year cardiac and all-cause death in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction?
P
Population
1,125 stabilized patients (no clinical events within 1 month post AMI) with type 2 diabetes mellitus after acute myocardial infarction (STEMI or NSTEMI), mean age 65, 66% male, from the Korean multicenter DIAMOND registry.
I
Intervention
Obesity (defined as body mass index ≥25 kg/m2)
C
Comparator
Non-obesity (defined as body mass index <25 kg/m2)
O
Outcome
2-year cardiac and all-cause deathhard clinical
In stabilized Asian patients with type 2 diabetes after acute myocardial infarction, obesity (BMI ≥25 kg/m2) is associated with a significantly lower risk of 2-year cardiac and all-cause mortality compared to non-obesity, demonstrating the obesity paradox in this population.
Limitations
- Did not present the range of BMI over which the association held, as only 3.6% of patients had a BMI ≥30 kg/m2
- Only used BMI, which might not be the ideal measure to discriminate between fat and lean body mass
- Might have underestimated the risk of mortality because clinical events are likely to occur in the acute stage after AMI presentation
- Did not control for the stent type which may have influenced study results
Cite This Study
Won et al. (2015) studied this question.
Topics
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