February 5, 2014Cardiovascular DiabetologyOpen Access

Changes in liraglutide-induced body composition are related to modifications in plasma cardiac natriuretic peptides levels in obese type 2 diabetic patients

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Why the study?

Does liraglutide improve body composition and increase plasma natriuretic peptide levels in obese type 2 diabetic patients?

Population

31 outpatients with type 2 diabetes and obesity, mean age 48.5, 16 male/15 female, on a stable dose of…

Design

Cohort, DXA and CT scans assessed by a single reader who was blinded to the…

Follow-up

12 weeks

Authors

CLChunjun LiNankai University QYQian YuNankai University PYPei YuCentral South University

Discussion

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Implication

Liraglutide weight loss in obese T2D correlates with ANP/BNP rises; hypothesis-generating for mechanism, needs randomized confirmation.

Structured PICO

Does liraglutide improve body composition and increase plasma natriuretic peptide levels in obese type 2 diabetic patients?

Population

31 outpatients with type 2 diabetes and obesity (BMI ≥28 kg/m2, HbA1c 7.0-10%), mean age 48.5, 16 male/15 female, on a stable dose of maximal metformin or combined with other oral anti-diabetes drugs (except TZDs).

Intervention

Liraglutide subcutaneous add-on therapy for 12 weeks, initiated at 0.6 mg once daily and titrated to 1.2 mg once daily after one week.

Outcome

Changes in body composition (body weight, waist circumference, total fat and lean mass, fat percentage, SAT and VAT areas) and plasma atrial natriuretic peptides (ANP) and B-type ventricular natriuretic peptides (BNP) concentrations at 12 weeks.surrogate

Liraglutide-induced weight loss and fat reduction in obese type 2 diabetic patients are significantly correlated with increases in plasma ANP and BNP levels, suggesting a potential novel mechanism for its weight-loss effects.

Limitations

lack of double-blind placebo-controlled design
single ethnicity (Chinese cohort only)

Cite This Study

Li et al. (2014) studied this question.

synapsesocial.com/papers/6a6fbeea2163a0a01bc403fd https://doi.org/10.1186/1475-2840-13-36

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Changes in liraglutide-induced body composition are related to modifications in plasma cardiac natriuretic peptides levels in obese type 2 diabetic patients

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Changes in liraglutide-induced body composition are related to modifications in plasma cardiac natriuretic peptides levels in obese type 2 diabetic patients

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider