September 26, 2011Drug Metabolism Reviews

Possibilities to increase the effectiveness of doxorubicin in cancer cells killing

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Population

Cancer cells and noncancerous tissues (focus on doxorubicin therapy)

Design

Review

Authors

VHVeronika HanušováCharles University IBIva BoušováCharles University LSLenka SkálováCharles University

Discussion

Member takes

Implication

Should not yet change doxorubicin practice; leaves open optimal strategies to enhance tumor selectivity while curbing cardiotoxicity.

Structured PICO

Population

Cancer cells and noncancerous tissues (focus on doxorubicin therapy)

Intervention

Strategies to increase doxorubicin efficacy (e.g., liposomal encapsulation, conjugation with antibodies/peptides/polymers, altered metabolism, restriction of efflux)

This review outlines strategies to enhance the anti-cancer efficacy of doxorubicin while mitigating its dose-limiting cardiotoxicity.

Cite This Study

Hanušová et al. (2011) studied this question.

synapsesocial.com/papers/6a6fbeeb5d37378ac1dccfde https://doi.org/10.3109/03602532.2011.609174

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Possibilities to increase the effectiveness of doxorubicin in cancer cells killing

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Possibilities to increase the effectiveness of doxorubicin in cancer cells killing

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider