June 28, 1996Science

Nonselective and G βγ -Insensitive weaver K + Channels

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Population

Homozygous weaver mice and cells expressing wvGIRK2 subunits

Design

Preclinical

Authors

BNBetsy NavarroClínica IVI Alicante MKMatthew KennedyMerck & Co., Inc., Rahway, NJ, USA (United States)BVBratislav M. VelimirovicMayo Clinic

Discussion

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Implication

No immediate clinical implications; leaves open GIRK2 mechanisms in human channelopathies.

Structured PICO

Population

Homozygous weaver mice and cells expressing wvGIRK2 subunits

Intervention

Expression of the weaver allele of the GIRK2 subunit (wvGIRK2) with Gly156-->Ser mutation

Outcome

K+ selectivity and sensitivity to G protein betagamma dimerssurrogate

The weaver mutation in the GIRK2 subunit causes loss of potassium selectivity and G protein sensitivity, leading to basal nonselective channel opening and increased cell death.

Cite This Study

Navarro et al. (1996) studied this question.

synapsesocial.com/papers/6a6fc10035aa2c282ce11824 https://doi.org/10.1126/science.272.5270.1950

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Nonselective and G βγ -Insensitive weaver K + Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nonselective and G βγ -Insensitive weaver K + Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider