Why the study?
PVI achieves modest long-term success, and alternative ablation targets have not established themselves as routine sites, prompting investigation into renal denervation to address sympathovagal imbalance.
Does renal denervation added to pulmonary vein isolation reduce atrial fibrillation recurrence in patients with atrial fibrillation and hypertension?
Does renal denervation added to pulmonary vein isolation reduce atrial fibrillation recurrence in patients with atrial fibrillation and hypertension?
Renal denervation is an emerging and promising adjunct therapy to pulmonary vein isolation that may improve long-term rhythm control in patients with atrial fibrillation and hypertension by modulating sympathovagal imbalance.
Alternative targets beyond PVI lack established efficacy in AF ablation; leaves open whether novel strategies can improve long-term outcomes.
The central anatomical locus in the context of atrial fibrillation (AF) ablation has been the pulmonary veins. Despite the attainment of a modest long-term success rate through pulmonary vein isolation (PVI), the pursuit of achieving a therapeutic efficacy nearing a definitive cure has spurred an investigation into alternative strategies and anatomical loci beyond the pulmonary veins. Despite extensive exploration, none of these alternative targets have succeeded in establishing themselves as routine ablation sites comparable to the pulmonary veins. Consequently, there exists an imperative for further inquiry and refinement of ablation strategies to propel advancements within the domain of AF ablation, thereby augmenting patient outcomes. Simultaneously, the examination of the autonomic system's role in AF pathophysiology introduces an additional ablation target aimed at rectifying sympathovagal imbalance. This discourse presents a contemporary review of renal denervation (RDN) as an emergent and auspicious technique poised to complement PVI, thereby contributing substantively to the augmentation of long-term success within the ambit of AF rhythm-control strategies.
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Akrawinthawong et al. (2024) studied this question.
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