What question did this study set out to answer?

To evaluate the mechanistic effects of low versus high FODMAP diets on clinical symptoms, the metabolome, and the gut microbiota in individuals with irritable bowel syndrome.

March 14, 2016Gut

FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial

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Authors

KMKeith McIntoshWestern University DRDavid E. ReedQueen's University TSTheresa SchneiderUniversitätsklinikum Würzburg

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Implication

Randomized trial reveals that a low FODMAP diet alters urinary metabolites and gut microbiota in patients with irritable bowel syndrome, suggesting immune and microbial drivers of symptoms.

Key Points

To evaluate the mechanistic effects of low versus high FODMAP diets on clinical symptoms, the metabolome, and the gut microbiota in individuals with irritable bowel syndrome.
Single-blind randomized controlled trial (NCT01829932) of 40 patients with IBS diagnosed by Rome III criteria, assigned to a low (n=20) or high (n=20) FODMAP diet for 3 weeks.
Outcomes were assessed using the IBS symptom severity scoring, lactulose breath testing, mass-spectrometry-based urinary metabolomic profiling, and fecal microbiota analysis via 16S rRNA gene sequencing.
Urinary metabolic profiles differed significantly between the low and high FODMAP groups following the 3-week intervention (p < 0.01), driven primarily by histamine, p-hydroxybenzoic acid, and azelaic acid.
Urinary histamine, an indicator of immune activation, was reduced eightfold in the low FODMAP group compared with controls (p < 0.05).
The low FODMAP diet increased Actinobacteria richness and diversity, whereas the high FODMAP diet decreased the relative abundance of gas-consuming bacteria.

Cite This Study

McIntosh et al. (2016) studied this question.

synapsesocial.com/papers/6a6fc28078a11c550e0986e4 https://doi.org/10.1136/gutjnl-2015-311339

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Implication

Randomized trial reveals that a low FODMAP diet alters urinary metabolites and gut microbiota in patients with irritable bowel syndrome, suggesting immune and microbial drivers of symptoms.

FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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