Cytogenetic causes for recurrent spontaneous abortions - An experience of 742 couples (1484 cases)

BACKGROUND: First trimester pregnancy loss is a very common and a matter of concern for couples planning pregnancy. chromosomal rearrangements in either parent is an important of recurrent pregnancy loss particularly in the first trimester. : In this study an evaluation of the contribution of chromosomal in causing repeated spontaneous abortions was made. METHODS MATERIALS: review of the cytogenetic data in 742 couples (1484 ) with recurrent spontaneous abortions who were examined for aberrations in the period 1990-2003 is presented. Women who at least two abortions, or spontaneous abortions preceded or by fetal deaths or birth of a malformed child, and patients had recurrent spontaneous abortions (> 3) with normal live /s were studied. RESULTS: Chromosomal rearrangements were found 31 individuals (2%). These abnormalities included 22 (2.9%) aberrations, 9 (1.2%) numerical anomalies. In addition to abnormalities, 21 (3.2%) chromosomal variants were also found. : Chromosomal analysis is an important etiological in couples with repeated spontaneous abortions as it in genetic counseling and deciding about further reproductive .