Inhibition of Phosphorylation of Glucose in Mouse Brains by Viruses and Its Prevention by Preparations of Diphosphopyridine Nucleotide

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Population

Mouse brain homogenates

Comparison

Preparations of diphosphopyridine nucleotide and… vs Untreated infected brain homogenates or normal…

Design

Preclinical

Authors

Discussion

Reversible glycolysis inhibition in murine viral encephalitis; hypothesis-generating for metabolic targets in human CNS infections.

Population

Mouse brain homogenates (from mice infected with poliomyelitis virus Lansing strain or Theiler FA strain, and normal mouse brains)

Intervention

Preparations of diphosphopyridine nucleotide (DPN) and glucose

Comparator

Untreated infected brain homogenates or normal brain-virus mixtures

Outcome

Inhibition of glycolysis/glucose utilizationsurrogate

The study demonstrates that viral infection inhibits glucose utilization in mouse brains, an effect that can be prevented by DPN and glucose.

Racker et al. (1946) studied this question.

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