Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy.

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Population

Freshly isolated T cells and resting T cells

Comparison

Calcium ionophore pretreatment before anti-CD3… vs Plate-bound anti-CD3 stimulation of resting T…

Design

Preclinical

Authors

Discussion

May mediate T-cell anergy via IL-2 translational control; leaves open therapeutic targeting in human autoimmunity or transplantation.

Population

Freshly isolated T cells and resting T cells

Intervention

Calcium ionophore pretreatment before anti-CD3 stimulation, or T cell receptor (TCR) stimulation without costimulatory signals

Comparator

Plate-bound anti-CD3 stimulation of resting T cells without calcium ionophore pretreatment

Outcome

IL-2 mRNA expression, ribosome loading (translation), and IL-2 secretionsurrogate

T cell anergy may be mediated by the translational control of IL-2 mRNA via differential ribosome loading.

García‐Sanz et al. (1996) studied this question.

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