Effect Of Accelerated Corneal Collagen Cross Linking (CXL) On Corneal Endothelium

Aim: To study the effect of accelerated collagen cross linking on corneal endothelial cell count and morphology in patients with progressive keratoconus. Design: Prospective non randomised interventional study. Material & Methods: 40 consecutive eyes that underwent corneal collagen cross linking with riboflavin (CXL) for keratoconus were included in the study. Corneal endothelial cell count and morphology were compared before CXL and after CXL. Results: In this study we found that with accelerated collagen cross linking change in endothelial cell count and coefficient of variance was statistically significant with P value of P<0.001 and P<0.004 respectively when compared preoperative values. Conclusion: There is effect of accelerated collagen cross linking on the corneal endothelial cell and morphology which needs to be further studied.