October 4, 2010The Journal of PhysiologyOpen Access

Hyperoxia blunts counterregulation during hypoglycaemia in humans: possible role for the carotid bodies?

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Why the study?

Does hyperoxia blunt neuro-hormonal counterregulation during hypoglycaemia in healthy adults?

Structured PICO

Does hyperoxia blunt neuro-hormonal counterregulation during hypoglycaemia in healthy adults?

Population

7 healthy adults (4 male, 3 female)

Intervention

Hyperoxia (P(aO2) 345 ± 80.6 mmHg) during a 180 min hyperinsulinaemic (2 mU (kg fat-free mass (FFM))(-1) min(-1)), hypoglycaemic (3.33 mmol l(-1)) clamp

Comparator

Normoxia (arterial P(aO2) 111 ± 6.3 mmHg) during a 180 min hyperinsulinaemic, hypoglycaemic clamp

Outcome

Glucose infusion rate and counterregulatory hormone levels (noradrenaline, adrenaline, cortisol, growth hormone, glucagon) during hypoglycaemiasurrogate

Hyperoxia blunts the counterregulatory hormone response to hypoglycaemia, suggesting the carotid bodies play a role in glucose sensing in humans.

Discussion

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Implication

Hyperoxia may blunt counterregulation in hypoglycemia; extends carotid body glucose-sensing role to humans.

Cite This Study

Wehrwein et al. (2010) studied this question.

synapsesocial.com/papers/6a6fc7da5671bbf00bc29b4b https://doi.org/10.1113/jphysiol.2010.197491

View Full Paper

Ask AI

Bookmark

Hyperoxia blunts counterregulation during hypoglycaemia in humans: possible role for the carotid bodies?

Structured PICO

Discussion

Implication

Cite This Study

Hyperoxia blunts counterregulation during hypoglycaemia in humans: possible role for the carotid bodies?

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider