Synthesis of Cored Dendrimers with Internal Cross-Links

Hydrolytic removal of the core unit and cross-linking of their wedges enables dendrimers to be “cored” (see schematic representation). By internalizing the alkenes, the ring-closing metathesis reaction will “stitch” the dendritic wedges together intramolecularly, even at dendrimer concentrations of 10−3 M. In contrast, peripheral alkenes react intermolecularly at this concentration.