Pregnancy in Penicillamine-Treated Patients with Wilson's Disease

UNTIL specific treatment with D-penicillamine became available for Wilson's disease, successful pregnancy was a rare occurrence except in patients who remained asymptomatic well into adult life.1 2 3 4 5 In the symptomatic young women amenorrhea and spontaneous abortions were frequent complications, and the neurologic and psychiatric disturbances of the disorder reduced the probability of marriage. Treatment with D-penicillamine6 has dramatically altered the course of this illness so that a normal reproductive life is the rule rather than the exception. In this study we attempt to resolve a dilemma created on one hand, by the necessity of continued therapy and, on the other, by . . .