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February 6, 2002Journal of the American Chemical Society

Microsomal P450-Catalyzed N-Dealkylation of N,N-Dialkylanilines:  Evidence for a Cα−H Abstraction Mechanism

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MBMehul N. BhaktaUniversity of Maryland, BaltimoreKWKandatege WimalasenaWichita State University

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Bhakta et al. (2002) studied this question.

synapsesocial.com/papers/6a6fc9b3a528af2d65c32b14https://doi.org/10.1021/ja011041d
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chemical mechanisms of catalysis by cytochromes P-450: a unified view1984 · 487 citations
  2. 2Mechanisms of N-Demethylations Catalyzed by High-Valent Species of Heme Enzymes:  Novel Use of Isotope Effects and Direct Observation of Intermediates1998 · 87 citations
  3. 3On isotope effects for the cytochrome P-450 oxidation of substituted N,N-dimethylanilines1993 · 84 citations
  4. 4A Kinetic Scale for Dialkylaminyl Radical Reactions1996 · 108 citations
  5. 5Electron transfer from nitrogen in microsomal oxidation of amine and amide. Simulation of microsomal oxidation by anodic oxidation1982 · 76 citations