What question did this study set out to answer?

To assess the short-term cardiovascular tolerability and safety of extended-release mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and medically controlled hypertension.

May 15, 2006The Journal of Clinical Psychiatry

An Open-Label Study of the Tolerability of Mixed Amphetamine Salts in Adults With Attention-Deficit/Hyperactivity Disorder and Treated Primary Essential Hypertension

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Authors

TWTimothy E. WilensBoston University RZRandall M. ZusmanMassachusetts General Hospital PHPaul HammernessBoston Medical Center

Discussion

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Implication

Open-label study demonstrates stable blood pressure with mixed amphetamine salts in adults with ADHD and treated hypertension, suggesting short-term cardiovascular tolerability.

Key Points

To assess the short-term cardiovascular tolerability and safety of extended-release mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and medically controlled hypertension.
An 8-week, 2-phase, open-label trial enrolled 13 adults with ADHD and primary essential hypertension who maintained blood pressure under 135/85 mm Hg on antihypertensive therapy for at least 4 weeks.
Participants received once-daily extended-release mixed amphetamine salts titrated up to 60 mg/day for 6 weeks (phase 1), followed by a 2-week medication discontinuation period (phase 2).
Assessments included manual blood pressure, pulse, electrocardiograms, and ADHD symptom rating scales across all visits.
All 13 participants completed the trial with no serious adverse events and no sustained blood pressure elevations (>140/90 mm Hg across two consecutive visits).
No group mean increases occurred in systolic blood pressure, diastolic blood pressure, or pulse during active treatment, and no clinically significant electrocardiogram abnormalities developed.
ADHD symptom severity significantly improved during the 6-week active treatment phase, with benefits reversing following drug discontinuation.

Cite This Study

Wilens et al. (2006) studied this question.

synapsesocial.com/papers/6a6fcbb1f44fa9f079dd4a1f https://doi.org/10.4088/jcp.v67n0502

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Implication

Open-label study demonstrates stable blood pressure with mixed amphetamine salts in adults with ADHD and treated hypertension, suggesting short-term cardiovascular tolerability.

An Open-Label Study of the Tolerability of Mixed Amphetamine Salts in Adults With Attention-Deficit/Hyperactivity Disorder and Treated Primary Essential Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

An Open-Label Study of the Tolerability of Mixed Amphetamine Salts in Adults With Attention-Deficit/Hyperactivity Disorder and Treated Primary Essential Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

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