Epitope Mapping of Foot-and-Mouth Disease Virus with Neutralizing Monoclonal Antibodies

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Population

Strain A22 Iraq 24/64 of foot-and-mouth disease virus

Design

Preclinical

Authors

Discussion

May guide FMDV antigen design; hypothesis-generating in animal models without translation to livestock.

Population

Strain A22 Iraq 24/64 of foot-and-mouth disease virus

Intervention

Epitope mapping using monoclonal antibodies (indirect ELISA, neutralization escape variants production and sequencing)

Outcome

Identification of neutralizing epitopessurrogate

Synthetic peptides representing the major antigenic site on VP1 elicit broad cross-neutralizing antibodies against foot-and-mouth disease virus.

Bolwell et al. (1989) studied this question.

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