What question did this study set out to answer?

To evaluate the mechanisms by which stress and glucocorticoids modulate reproductive axis function across non-rodent mammalian species, with a focus on sex differences.

May 1, 2000Reviews of ReproductionOpen Access

Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences

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To evaluate the mechanisms by which stress and glucocorticoids modulate reproductive axis function across non-rodent mammalian species, with a focus on sex differences.
Synthesized comparative endocrinological literature on acute and chronic stress responses in non-rodent mammalian models.
Evaluated stress effects across different levels of the reproductive axis, including hypothalamic GnRH secretion, pituitary gonadotrophin release, and circulating cortisol dynamics.
Stress disrupts reproductive function predominantly at the level of the hypothalamus (suppressing GnRH secretion) and pituitary gland (altering gonadotrophin release), with direct gonadal effects playing a minimal role.
Short-term stressors often have no measurable impact or occasionally stimulate reproduction, whereas prolonged elevations in circulating cortisol are typically required to cause reproductive deficits.
Reproductive sensitivity to stressors varies significantly across species and between sexes, reflecting distinct regulatory actions along different tiers of the hypothalamo-pituitary axis.

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Implication

Narrative review demonstrates divergent reproductive responses to stress in non-rodent mammals, highlighting the critical roles of sex, exposure duration, and cortisol dynamics.

Cite This Study

A. Tilbrook (2000) studied this question.

synapsesocial.com/papers/6a6fcfa075498292b7093129 https://doi.org/10.1530/revreprod/5.2.105

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Implication

Narrative review demonstrates divergent reproductive responses to stress in non-rodent mammals, highlighting the critical roles of sex, exposure duration, and cortisol dynamics.

Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences

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Implication

Cite This Study

Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences

Key Points

Discussion

Implication

Cite This Study

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