Why the study?
What is the incidence and nature of severe reactions following the administration of Wellcome pertussis vaccines?
Population
Individuals receiving Wellcome pertussis vaccines in the United Kingdom and Northern Ireland from 1964 to…
Design
Review
Authors
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Rare severe events after millions of doses should not change practice; leaves open precise causality assessment in vaccine safety reviews.
What is the incidence and nature of severe reactions following the administration of Wellcome pertussis vaccines?
This historical pharmacovigilance review highlights the challenges in attributing severe adverse events to specific pertussis vaccines due to background rates of neurological disorders in infants and lack of detailed clinical information.
A.H. Griffith (1978) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: