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April 1, 2010Current Opinion in Endocrinology Diabetes and Obesity

Brown fat as a therapy for obesity and diabetes

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Population

Adult humans with or at risk for obesity and diabetes

Design

Review

Authors

ACAaron M. CypessWest Virginia University
C. Ronald Kahn
C. Ronald KahnUniversity of Geneva

Discussion

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Overview

Supports BAT as obesity target; leaves open whether activation improves outcomes in trials.

Structured PICO

P
Population
Adult humans with or at risk for obesity and diabetes
I
Intervention
Therapies targeting brown adipose tissue (BAT) to increase energy expenditure
O
Outcome
Weight loss and improved metabolic profile

The conclusive identification of functional brown adipose tissue in adult humans opens new therapeutic avenues for treating obesity and diabetes through increased energy expenditure.

Cite This Study

Cypess et al. (2010) studied this question.

synapsesocial.com/papers/6a6fd2e2e71d69abee08399fhttps://doi.org/10.1097/med.0b013e328337a81f
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.1995 · 557 citations
  2. 2Thermogenesis in human brown adipose tissue and skeletal muscle induced by sympathomimetic stimulation1986 · 70 citations
  3. 3High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans2009 · 1,858 citations
  4. 4Sirtuin Functions in Health and Disease2007 · 481 citations