September 27, 2007Molecular Biology of the Cell

Cytoplasmic Relocalization of Heterogeneous Nuclear Ribonucleoprotein A1 Controls Translation Initiation of Specific mRNAs

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Population

HeLa cells, 293T cells, and in vitro translation models

Comparison

Modulation of hnRNP A1 subcellular localization… vs Control conditions

Design

Preclinical

Authors

ACAnne CammasCentre National de la Recherche Scientifique FPFrédéric PileurUniversité Toulouse III - Paul Sabatier SBSophie BonnalCentre for Genomic Regulation

Discussion

Member takes

Implication

May modulate IRES translation in viral infection or apoptosis; leaves open therapeutic relevance in human cardiovascular disease.

Structured PICO

Population

HeLa cells, 293T cells, and in vitro translation models

Intervention

Modulation of hnRNP A1 subcellular localization via human rhinovirus infection, UVC irradiation, or siRNA-mediated knockdown

Comparator

Control conditions (mock infection, no UVC irradiation, control siRNA)

Outcome

IRES-mediated translation activity and hnRNP A1 binding to HRV and apaf-1 mRNAssurrogate

This study demonstrates that the subcellular relocalization of the nuclear mRNA-binding protein hnRNP A1 regulates protein synthesis by acting as an IRES trans-acting factor.

Cite This Study

Cammas et al. (2007) studied this question.

synapsesocial.com/papers/6a6fd2e4febe604dd708a9cd https://doi.org/10.1091/mbc.e07-06-0603

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Cytoplasmic Relocalization of Heterogeneous Nuclear Ribonucleoprotein A1 Controls Translation Initiation of Specific mRNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cytoplasmic Relocalization of Heterogeneous Nuclear Ribonucleoprotein A1 Controls Translation Initiation of Specific mRNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider