January 1, 2007PLoS Computational BiologyOpen Access

Mechanochemical Coupling in the Myosin Motor Domain. II. Analysis of Critical Residues

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Population

Dictyostelium discoideum myosin II motor domain

Design

Preclinical

Authors

HYHaibo YuSinopec (China)LMLiang MaUniversity of Science and Technology Beijing YYYang YangChinese Academy of Sciences

Discussion

Member takes

Implication

Findings remain preclinical; leaves open validation of myosin residues in human cardiac models.

Structured PICO

Population

Dictyostelium discoideum myosin II motor domain

Intervention

Targeted molecular dynamics, normal mode analysis, and statistical coupling analysis

Outcome

Identification of critical residues and their relevant function during the recovery stroke of myosin

The study identifies critical 'hotspot' residues in the myosin motor domain that dictate mechanochemical coupling, highlighting the value of combining physically motivated and informatics-driven computational techniques.

Cite This Study

Yu et al. (2007) studied this question.

synapsesocial.com/papers/6a6fd37dc1a24a6142db6663 https://doi.org/10.1371/journal.pcbi.0030023

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Bookmark

Mechanochemical Coupling in the Myosin Motor Domain. II. Analysis of Critical Residues

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanochemical Coupling in the Myosin Motor Domain. II. Analysis of Critical Residues

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider