There is considerable and growing evidence that chronic microglial activation plays a major role in numerous neurological conditions including Alzheimer's dementia, Parkinson's disease, ALS, strokes, and inflammatory brain diseases. The release of toxic elements from activated microglia, such as cytokines and excitotoxins, is known to produce neurodegeneration. Peripheral immune stimulation has been shown to activate CNS microglia, and when excessive can lead to neurodegeneration and cognitive defects commonly associated with both the Gulf War Syndrome (GWS) and autism. This paper summarizes the mechanism linking these two disorders with excessive immune stimulation secondary to overvaccination.
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Giannotta et al. (2019) studied this question.
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