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June 1, 2007Circulation ResearchOpen Access

Organization of Ventricular Fibrillation in the Human Heart

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Population

Detailed computational model of the human ventricles, including cell electrophysiology, ventricular anatomy…

Comparison

Simulation of ventricular fibrillation vs Ventricular fibrillation in large animal hearts

Design

Preclinical

Authors

KTKirsten ten TusscherUniversity of Applied Sciences UtrechtRHRok HrenInstitute of Mathematics, Physics, and MechanicsAPAlexander V. PanfilovUniversity College Ghent

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Overview

Simulated human VF organization challenges animal model reliance; leaves open clinical translation of rotor-targeted interventions.

Structured PICO

P
Population
Detailed computational model of the human ventricles, including cell electrophysiology, ventricular anatomy, and fiber direction anisotropy
I
Intervention
Simulation of ventricular fibrillation
C
Comparator
Ventricular fibrillation in large animal hearts
O
Outcome
Number of reentrant sources (rotors) driving ventricular fibrillation

Computational modeling suggests human ventricular fibrillation is driven by significantly fewer reentrant sources than in large animal models, primarily due to differences in minimum action potential duration, which may inform future antiarrhythmic strategies.

Cite This Study

Tusscher et al. (2007) studied this question.

synapsesocial.com/papers/6a6fd41e26a7f98052dc6a6dhttps://doi.org/10.1161/circresaha.107.150730
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventricular fibrillation in myopathic human hearts: mechanistic insights from in vivo global endocardial and epicardial mapping2007 · 104 citations
  2. 2Incidence, Evolution, and Spatial Distribution of Functional Reentry During Ventricular Fibrillation in Pigs1999 · 93 citations
  3. 3Regional Differences in Ventricular Fibrillation in the Open-Chest Porcine Left Ventricle2002 · 47 citations
  4. 4Estimated Global Transmural Distribution of Activation Rate and Conduction Block During Porcine and Canine Ventricular Fibrillation2004 · 70 citations
  5. 5Effect of remodelling, stretch and ischaemia on ventricular fibrillation frequency and dynamics in a heart failure model2004 · 44 citations