Population
Preclinical cell models (HEK293T cells, 293TRex cells, and E. coli for recombinant protein expression)
Comparison
Overexpression or RNAi-mediated depletion of p72… vs Control cells, empty vector, or control shRNA
Design
Preclinical
Authors
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p72 supports ZAP antiviral function; leaves open its relevance to human viral therapies pending further validation.
The p72 DEAD box RNA helicase directly interacts with the zinc-finger antiviral protein (ZAP) and is required for its optimal function in mediating viral mRNA degradation.
Chen et al. (2008) studied this question.
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