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September 1, 2014Clinical Interventions in AgingOpen Access

General anesthetic and the risk of dementia in elderly patients: current insights

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Why the study?

Does exposure to surgery and general anesthesia increase the risk of dementia or Alzheimer's disease in elderly patients?

Population

Elderly patients

Comparison

Surgery and general anesthesia vs No surgery, or other types of anesthesia

Design

Review

Authors

DSDallas SeitzMHMaria HussainRERoderic G. Eckenhoff

Discussion

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Overview

Does not warrant avoiding general anesthesia in elderly; leaves open need for prospective trials on dementia risk.

Structured PICO

Does exposure to surgery and general anesthesia increase the risk of dementia or Alzheimer's disease in elderly patients?

P
Population
Elderly patients
I
Intervention
Surgery and general anesthesia
C
Comparator
No surgery, or other types of anesthesia (e.g., epidural)
O
Outcome
Dementia, particularly Alzheimer's disease (AD)hard clinical

Current evidence is inconsistent regarding the association between general anesthesia, surgery, and the subsequent risk of dementia or Alzheimer's disease in elderly patients.

Limitations

  • Inconsistent evidence
  • Lack of well-designed and adequately powered studies with long follow-up periods

Cite This Study

Seitz et al. (2014) studied this question.

synapsesocial.com/papers/6a6fd4945671bbf00bc29cb2https://doi.org/10.2147/cia.s49680
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Optimised Anaesthesia to Reduce Post Operative Cognitive Decline (POCD) in Older Patients Undergoing Elective Surgery, a Randomised Controlled Trial2012 · 245 citations
  2. 2Postoperative Cognitive Dysfunction in Middle-aged Patients2002 · 384 citations
  3. 3Presynaptic Cholinergic Dysfunction in Patients with Dementia1983 · 419 citations
  4. 4Coronary Artery Bypass Surgery Provokes Alzheimer's Disease-Like Changes in the Cerebrospinal Fluid2010 · 87 citations
  5. 5Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly2008 · 1,062 citations