Why the study?
Inflammatory cells are recruited to infarcted myocardium, but the function of leukotriene B4 receptor 1 (BLT1) in myocardial infarction was poorly understood.
Does BLT1 inhibition or knockout reduce inflammation and improve cardiac function and survival in mice after myocardial infarction?
Population
Mice with infarcted hearts
Comparison
BLT1 knockout or ONO-4057 administration vs control
Design
Preclinical animal study including bone-marrow transplantation
Authors
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BLT1 antagonism attenuates murine MI injury; hypothesis-generating for human translation and requires clinical trials.
Does BLT1 inhibition or knockout reduce inflammation and improve cardiac function and survival in mice after myocardial infarction?
Inhibition of the leukotriene B4 receptor 1 (BLT1) reduces post-MI inflammation, cell death, and mortality while improving cardiac function in mice, highlighting a potential novel therapeutic target.
Horii et al. (2020) studied this question.
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