Why the study?
Does the magnitude of initial ST segment elevation and depression predict infarct size limitation by intravenous recombinant tissue-type plasminogen activator in patients with acute myocardial infarction?
Population
655 patients with acute myocardial infarction from an initial cohort of 721 patients.
Comparison
Intravenous recombinant tissue-type plasminogen… vs Placebo
Design
RCT, randomized, placebo-controlled
Follow-up
Hospital discharge (72 hours for enzymatic infarct size)
Authors
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Large admission ST deviations identify AMI patients with greatest rt-PA benefit; supports ECG-based stratification in thrombolysis trials.
Does the magnitude of initial ST segment elevation and depression predict infarct size limitation by intravenous recombinant tissue-type plasminogen activator in patients with acute myocardial infarction?
The magnitude of initial ST elevation and reciprocal ST depression on the admission ECG is valuable for predicting the benefit of thrombolytic therapy in acute myocardial infarction.
Willems et al. (1990) studied this question.
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