What question did this study set out to answer?

To determine whether a chemically generated reflex in nonischemic skeletal muscle increases sympathetic outflow during rhythmic exercise.

December 1, 1989AJP Heart and Circulatory Physiology

Reflex stimulation of sympathetic outflow during rhythmic exercise in humans

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Why the study?

Does a chemically generated reflex arising in nonischemic skeletal muscle normally increase sympathetic outflow during rhythmic exercise in humans?

Key Points

To determine whether a chemically generated reflex in nonischemic skeletal muscle increases sympathetic outflow during rhythmic exercise.
Recorded muscle sympathetic nerve activity (MSNA) from the peroneal nerve in conscious humans during rhythmic handgrip (0.67 Hz) and one-arm cycling (0.83 Hz) at mild and moderate intensities.
Evaluated sympathetic responses under normal circulation and with complete or partial vascular occlusion to sustain or augment muscle chemoreflex activation.
MSNA increased during moderate levels of rhythmic handgrip and one-arm cycling, but did not increase during mild exercise under normal blood flow conditions.
MSNA remained elevated during post-exercise forearm vascular occlusion following moderate handgrip, while complete or partial arm vascular occlusion was required to trigger or amplify MSNA during arm cycling.

Structured PICO

Does a chemically generated reflex arising in nonischemic skeletal muscle normally increase sympathetic outflow during rhythmic exercise in humans?

Population

Conscious humans

Intervention

Rhythmic handgrip (0.67 Hz) and one-arm cycling (0.83 Hz) at mild and moderate levels, with and without forearm or complete arm vascular occlusion

Comparator

Baseline or different levels of exercise intensity and vascular occlusion

Outcome

Muscle sympathetic nerve activity (MSNA, peroneal nerve)surrogate

A chemically generated reflex in nonischemic working muscle plays an important role in activating sympathetic discharge to nonexercising muscles during moderate rhythmic arm exercise.

Discussion

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Implication

May support muscle chemoreflex contribution to sympathetic activation during moderate rhythmic exercise; leaves open relevance to clinical populations or practice change.

Cite This Study

Victor et al. (1989) studied this question.

synapsesocial.com/papers/6a6fd7ce26a7f98052dc6d0c https://doi.org/10.1152/ajpheart.1989.257.6.h2017

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Implication

May support muscle chemoreflex contribution to sympathetic activation during moderate rhythmic exercise; leaves open relevance to clinical populations or practice change.

Reflex stimulation of sympathetic outflow during rhythmic exercise in humans

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Reflex stimulation of sympathetic outflow during rhythmic exercise in humans

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider