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One of the crucial problems in radiation protection is the reality of the negligible dose or de minimus concept (1-4). This issue of a practical zero and its resolution is central to our understanding of the controversy concerning the existence of a safe dose in radiological health. However, for very low levels of environmental mutagens and carcinogens including low doses of low-LET radiations (less than I cGy or 1 rad), spontaneous or endogenous DNA damage may have an increasing impact on the biological consequences of the induced cellular response. It is this issue that is addressed in this communication.
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Daniel Billen (1990) studied this question.
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